Senior Staff Scientist in the Thomas Lab at Fred Hutch Cancer Center (Seattle, WA) - 2026-Present
PhD in Biostatistics and Bioinformatics (2021) 👨💻👨🔬
- 🐢 TIRTLtools - An R package for processing, analysis, and visualization of T-cell receptor repertoire data created using TIRTL-seq, a novel T-cell receptor sequencing (TCR-seq) assay that extracts paired-chain αβ-TCR data from biological samples at a significantly lower cost than single-cell TCR sequencing.
- Bioinformatics Research Scientist in the Thomas Lab at St. Jude Children's Research Hospital (Memphis, TN) - 2025-2026
- Postdoctoral Research Fellow in the Laboratory for Systems Pharmacology (PI: Peter K. Sorger) at Harvard Medical School (Boston, MA). - 2021-2025
- Graduate Research Assistant in the The Laboratory for Statistical Genomics and Systems Biology (PI: Mario Medvedovic) at University of Cincinnati (Cincinnati, OH). - 2014-2021
- 🧬 iPAS (integrative Pathway Activity Signatures) - A method for construction of transcriptional signatures that are broadly predictive of signaling pathway perturbation in cancer cell lines. Our method combines data from many cell lines to create "ensemble" signatures with improved performance. Pre-print available on BioRxiv and R package available https://github.com/NicholasClark/iPAS/.
- 🧫 iLINCS - A web portal for analyzing transcriptional data using perturbation signatures from the LINCS project. Published in Nature Communications Pilarczyk et al..
- 📐 GRmetrics R package - A software package for implementing improved cell viability metrics based on changes in growth-rate due to drug treatment. Based on the work of Hafner et al. (Nature Methods)
- 🧮 GR Calculator - A user-friendly web extension of the GRmetrics R package, Clark et al. (BMC Cancer)
- 🧪 Small Molecule Suite - A web tool to help scientists understand the targets of molecular probes, approved drugs, and other drug-like molecules. Based on the work of Moret et al. (Cell Chemical Biology)